Waterhemp and Palmer amaranth are among the most troublesome and hard to control weeds in soybean fields in Kentucky. Both species have spread across the state over the past ten to fifteen years. Resistance to ALS-inhibiting herbicides [Group 2] and glyphosate [Group 9] is widespread in both species, while PPO-resistance [Group 14] is continually spreading especially in waterhemp. Herbicide manufacturers have developed several herbicide premix formulations targeted at controlling waterhemp and Palmer amaranth that contain multiple effective sites of action, thus farmers have options to choose from.